This document identifies knowledge gaps and challenges in healthcare epidemiology research related to coronavirus disease 2019 (COVID-19), including those related to nursing homes and social disparities, described in 10 sections: epidemiology, outbreak investigation, surveillance, isolation precaution practices, personal protective equipment (PPE), environmental contamination and disinfection, drug and supply shortages, antimicrobial stewardship, healthcare personnel (HCP) occupational safety, and return to work policies. Each section highlights three healthcare epidemiology research questions.

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